Researchers from the United States and Japan recently announced that they have developed a cow embryo that does not produce prion protein through genetic modification. Because this protein mutation can lead to "mad cow disease," the researchers believe that the cows developed from these embryos are likely to be free of "mad cow disease." Both healthy and mad cows produce prions in cattle. The prion protein in the diseased cow has been mutated and spread rapidly in the brain of the cow, causing poor coordination and behavioral problems, eventually leading to the death of the diseased cattle. According to the â€œNatureâ€ magazineâ€™s website on the 3rd, scientists from the United States and Japan have developed a cow embryo that does not produce prions at all, in order to thoroughly solve the â€œmad cow diseaseâ€ problem. They first extracted the prion protein gene sequence from bovine somatic cells, and then inserted it into the gene sequence with an artificial DNA fragment to prevent the gene from functioning normally. Then, they reinjected this modified gene sequence into the bovine body cells, and then developed the bovine embryo through cloning. At present, these embryos have been implanted in cows. The researchers said that if the embryos develop normally, transgenic cows free of mad cow disease will be born early next year. Of course, after the birth of the calves, they also have to use scientific methods to test whether they are certain they will not develop "mad cow disease." Scientists in charge of the study said in an interview with the website that they eventually wanted to use this genetically modified cow to cultivate "Crayon disease," the antibody commonly known as "mad cow disease." BSE is called "bovine spongiform encephalopathy," a zoonotic disease in which the brain, spine and eyes are mostly infected. If humans eat products made of diseased animals, they may be infected with CJD.
1.Good safety of gelatin-free.The first lyophilized Varicella Vaccine, containing no gelatin from animals, invented and produced in China. Getting rid of gelatin from varicella vaccine can significantly decrease the ratio of anaphylaxis incidence .
2.Long validity period by good stability. The first approved varicella vaccine with 36 months of validity period in the world. Adopting BH-2 stabilizer with own IP rights (Chinese patent granted No.: ZL200910138411.6, International patent application No.: PCT/CN2009/001405) greatly enhances the stability of the product and ensures the validity period for 36 months under the storage condition.
3.Better protection with high titer and immune efficacy. It`s documented that compared with the varicella vaccine of low titer, high titer vaccine can reduce breakthrough cases by nearly 75% in vaccination. Of all released batches of Varicella Vaccine from BCHT, the titers are not less than 10000 PFU/dose tested by National Institutes for Food and Drug Control.
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